Nb-SBA-15 mesoporous molecular sieve was synthesized in the co-impregnation method. The sample was characterized by XRD and BET, showing: Nb-SBA-15 melecular sieve had still highly ordered two-diemensional hexagonal mesoporous structure. The investigation on Nb-SBA-15 synthesis of isoproyl oleic shows that the mass fraction of Nb is 15%, molar ratio of alcohol and oleic acid is 2.5∶1，reaction temperature is 170 ℃，reaction time is 4 h, the yield of isoproyl oleic is up to 64.24%.